Product Description
This volume covers all important aspects of drug resistance in leukemia and lymphoma. General mechanisms of resistance are discussed, including the drug resistance related proteins, MRP (multi drug resistance protein) and LRP (lung resistance protein), and the role of glutathione and glutathione-S-transferases, as well as drug-specific mechanisms of resistance, apoptosis and its regulators and modulation of drug resistance…. More >>
Product Description
In the last decade many studies have been performed in the field of drug resistance. This book reviews the current status and indicates future directions of such studies. Both laboratory scientists and clinicians have recognized the importance of drug resistance for the clinical outcome of patients with leukemia and lymphoma. New in vitro cell culture assays have been developed and the in vitro drug resistance measured with these assays has been shown to correlate with both short and long-term clinical response to chemotherapy. This book is, therefore, an essential guide for researchers and clinicians.
Drug Resistance in Leukemia and Lymphoma contains material presented at the 2nd International Symposium in … More >>
Product Description
The last ten years have seen the publication of a vast amount of data regarding cellular resistance to drugs in cancer cells. Recent studies have demonstrated that drug resistance assays appear to be predictive of clinical response and suggest that clinicians should now be considering the potential applications of these assays in the treatment of patients with hematological neoplasms. This collection of papers from the International Symposium on the Clinical Value of Drug Resistance Assays in Leukemia and Lymphoma, Amsterdam, 1992, provides a state-of-the-art discussion on drug resistance assays and their role in the design and individualization of treatment protocols…. More >>
